We are trying to decipher how different subunits of NMDA-receptors initiate distinct signalling mechanisms at the synapse (but also outside of it) and how these translate into different synaptic responses, such as synaptic potentiation or depression, as well as instigate disease. In parallel, we study how patient-derived mutations in NMDAR-subunits affect receptor function and drive neural dysfunction, seizures, and degeneration. To address these questions, we develop unique optical, chemical and genetic technologies for labelling, manipulating and recording synaptic activities.
The projects in the lab revolve around:
Biophysical characterisation of NMDARs
Engineering light-gated receptors
Synthesising fluorescence, MRI and CT-compatible contrast-agents
Designing novel genetically encoded fluorescent probes
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